The largest city and airport in the Hawaiian Islands, Honolulu acts as a natural gateway to the islands’ large tourism industry, which brings millions of visitors and contributes $10 billion annually to the local economy. Honolulu’s location in the Pacific also makes it a large business and trading hub, particularly between the East and the West. Other important aspects of the city’s economy include military defense, research and development, and manufacturing. Among the companies based in Honolulu are Alexander & Baldwin, Bank of Hawaii, Central Pacific Bank, First Hawaiian Bank, Hawaii Medical Service Association, Hawaii Pacific Health, Hawaiian Electric Industries, Matson Navigation Company and The Queen’s Health Systems.